Role of ribosomal protein S19 oligomer-C5a receptor system in acute inflammation resolution
نویسندگان
چکیده
منابع مشابه
Ribosomal protein S19 expression during erythroid differentiation.
The gene encoding ribosomal protein S19 (RPS19) has been shown to be mutated in 25% of the patients affected by Diamond-Blackfan anemia (DBA), a congenital erythroblastopenia. As the role of RPS19 in erythropoiesis is still to be defined, we performed studies on RPS19 expression during terminal erythroid differentiation. Comparative analysis of the genomic sequences of human and mouse RPS19 gen...
متن کاملRibosomal protein S19 - 631 insertion is an African-originated mutation.
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. RPS19 gene encodes a ribosomal protein (RP) that is a component of the 40S subunit. The protein belongs to the S19E family of RPs. It is located in the cytoplasm. Mutations in this gene cause DiamondBlackfan anemia (DBA), a constitutional erythroblastopenia characterized by absent ...
متن کاملAnalysis of the Ribosomal Protein S19 Interactome*□S
Ribosomal protein S19 (RPS19) is a 16-kDa protein found mainly as a component of the ribosomal 40 S subunit. Its mutations are responsible for Diamond Blackfan anemia, a congenital disease characterized by defective erythroid progenitor maturation. Dysregulation of RPS19 has therefore been implicated in this defective erythropoiesis, although the link between them is still unclear. Two not mutu...
متن کاملRED CELLS Ribosomal protein S19 expression during erythroid differentiation
The gene encoding ribosomal protein S19 (RPS19) has been shown to be mutated in 25% of the patients affected by DiamondBlackfan anemia (DBA), a congenital erythroblastopenia. As the role of RPS19 in erythropoiesis is still to be defined, we performed studies on RPS19 expression during terminal erythroid differentiation. Comparative analysis of the genomic sequences of human and mouse RPS19 gene...
متن کاملRP S19 C-terminal peptide trimer acts as a C5a receptor antagonist
We have demonstrated that ribosomal protein S19 (RP S19) polymer, when crosslinked between Lys122 and Gln137 by activated coagulation factor XIII, acts as a C5a receptor (C5aR) antagonist/agonist. Based on experimental data obtained using RP S19 analog peptide and recombinant protein monomer, we suggested that L131DR, I134AGQVAAAN and K143KH moieties in the RP S19 C-terminus act in, respectivel...
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ژورنال
عنوان ژورنال: Microvascular Reviews and Communications
سال: 2014
ISSN: 1880-5906
DOI: 10.14532/mvrc.7.24